Where Suvo's supplement rules come from
When Suvo flags an interaction, timing issue, duplicate compound, or dose limit, the rule should be traceable to a named source. This library lists the references we use and explains how each one fits into the evidence hierarchy.
We treat supplement guidance as health-adjacent information. That means a government or regulatory source outranks a commercial database, systematic reviews outrank isolated studies, and chemical registries are used for identity and synonyms rather than clinical advice. Suvo is educational and does not replace advice from a qualified clinician.
Tier 1 — Regulatory authorities
Regulatory and national reference bodies are used first for tolerable upper limits, nutrient baselines, and safety thresholds.
Tier 2 — Authoritative institutes
Government institutes, systematic reviews, drug-label repositories, and clinical databases support interaction and timing rules when regulatory sources are silent.
- NIH Office of Dietary Supplements (NIH ODS)
- Cochrane Systematic Reviews
- DrugBank
- DailyMed
- MedlinePlus
Tier 3 — Academic centres
Academic monographs help resolve questions about micronutrients, botanicals, and mechanisms, especially where consumer-facing sources are too shallow.
Tier 4 — Commercial databases
Commercial and registry databases are useful completeness checks. They do not override stronger regulatory or government references.
How Suvo uses conflicts
If sources disagree, Suvo chooses the most conservative user-facing guidance and keeps the rule narrow. A source can support one type of rule without supporting another: PubChem may identify a compound synonym, while EFSA or NIH ODS handles the safety threshold. We avoid presenting uncertain findings as medical instructions.